GET THE APP

In vitro cytotoxicity and molecular docking studies on Acanthophora spicifera | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

In vitro cytotoxicity and molecular docking studies on Acanthophora spicifera

Author(s): Meenakshi Sundaram Muthuraman*, Sathiyamoorthi Mani, Udhayachandran Thangaraj and Aravind Sivasubramanian

Acanthophora spicifera, the red algae which is used as fresh vegetables in some parts of Vietnam and the Philippines was subjected to different solvent extraction (Hexane, Ethylacetate and Ethanol) and the ethanol extract of the Acanthophora spicifera was screened against the following strains Escherichia coli, Proteus vulgaris, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeuroginosa, Bacillus subtilis and also subjected to the in-vitro cytotoxic assay. From the data obtained it was evident that the extract showed significant increase in the death rate of Ehrlich Ascites carcinoma cell lines. At the dose level of 100μg/ml, 36.46% of cell death was noticed. With GC-MS (Gas chromatography Mass spectrometry) technique, 42 compounds were identified. Five of the compounds were docked with the BCL-2 protein by using Auto Dock software. The compound Phenol, 3-methyl-5- (1-methylethyl)-, methylcarbamate showed least binding energy of -9.3. In this study, it is confirmed that the Acanthophora spicifera has significant anti-cancer activity.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry