Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
In vitro cytotoxicity and molecular docking studies on Acanthophora spicifera
Author(s): Meenakshi Sundaram Muthuraman*, Sathiyamoorthi Mani, Udhayachandran Thangaraj and Aravind SivasubramanianAcanthophora spicifera, the red algae which is used as fresh vegetables in some parts of Vietnam and the Philippines was subjected to different solvent extraction (Hexane, Ethylacetate and Ethanol) and the ethanol extract of the Acanthophora spicifera was screened against the following strains Escherichia coli, Proteus vulgaris, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeuroginosa, Bacillus subtilis and also subjected to the in-vitro cytotoxic assay. From the data obtained it was evident that the extract showed significant increase in the death rate of Ehrlich Ascites carcinoma cell lines. At the dose level of 100μg/ml, 36.46% of cell death was noticed. With GC-MS (Gas chromatography Mass spectrometry) technique, 42 compounds were identified. Five of the compounds were docked with the BCL-2 protein by using Auto Dock software. The compound Phenol, 3-methyl-5- (1-methylethyl)-, methylcarbamate showed least binding energy of -9.3. In this study, it is confirmed that the Acanthophora spicifera has significant anti-cancer activity.
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