Abstract

Ikk-Alpha Role in Colorectal Cancer - A Contemporary Anti-Cancer Target For Prioritising Colorectal Cancer Research

Author(s): Anitha L* and Sinoy Sugunan

The IKK-alpha, B kinase, or IKK enzyme complex is involved in the propagation of the cellular response to inflammation. The upstream NF-B signal transduction cascade includes the IB kinase enzyme complex. By masking the nucleus localization signals (NLS) of NF-B proteins and keeping them sequestered in an inactive state in the cytoplasm, the IKB alpha (inhibitor of nuclear factor kappa B) protein inactivates the NF-B transcription factor. IKK phosphorylates the inhibitory IB protein in particular. The separation of IB from NF-B occurs as a result of this phosphorylation. Now that NF-B is liberated, it migrates into the nucleus and activates at least 150 genes, some of which are anti-apoptotic. FL-IKK must be proteolytically cleaved into p45-IKK in order to avoid the formation of p45-IKK.The proteolytic cleavage of FL-IKK into p45-IKK is essential for colorectal cancer cells to avoid apoptosis in vitro and to maintain tumour development in vivo. As a result, inhibiting IKK-alpha is a promising therapeutic target for colorectal cancer. The purpose of this review is to look at the involvement of IKK-alpha in colorectal cancer.

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