Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
HPTLC Method for the Estimation of Buclizine Hydrochloride (BUC) From Pure and Tablet Dosage Form
Author(s): Moreshwar P Mahajan and Arun M. Kashid*A simple, selective, accurate, and precise High-Performance Thin-Layer chromatographic (HPTLC) method has been developed and validated for analysis of the Buclizine Hydrochloride (BUC) in bulk drug and pharmaceutical formulations. HPTLC was performed on aluminium sheets precoated with silica gel G 60F254 as a stationary phase. The mobile phase chosen for development consists of chloroform: ethyl acetate in the ratio of 8:2 (v/v). Buclizine Hydrochloride (BUC) showed good linear regression analysis over the concentration ranges 100-600 ng per spot with correlation coefficients (R2) = 0.999. The developed method was validated as per ICH guidelines for precision, recovery, robustness, and specificity. The developed method can be applied for the quality control of commercial samples of Buclizine Hydrochloride (BUC) API and its different formulations.
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