Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Green synthesis of dispiroheterocycles through a microwave induced solvent free approach and a study on its biological activity
Author(s): Augustine Arul Prasad T. , Varadharajan E and Scholastica Mary Vithiya B.1, 3 dipolar cycloaddition reactions offer a versatile route for the synthesis of multi component heterocyclic molecules. Solvent-free Claisen-Schmidt reactions of cycloalkanones with various substituted benzaldehydes (aryl aldehydes) using solid NaOH (20 mol%) and applying a grinding technique is used to synthesize Quantitative yields of α,Ã?ŽÃ?¬-bis-(substitutedbenzylidene) cycloalkanones. Using the same technique we could synthesize the corresponding bis-benzylidene- and monobenzylideneacetone derivatives. The derivatives are then subjected to 1,3 dipolar cycloaddition reaction with azomethine ylides to yield the corresponding dispiroheterocycles through a microwave induced solvent free approach.
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