Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Gold Nanoparticles Catalyzed Synthesis of Ibuprofen Intermediate in Aqueous Ethanol
Author(s): Sandeep J Pawar, Shivkumar Y Patil, Pramod P Mahulikar and Vishwanath S ZopeIbuprofen was globally consumed drug in huge quantity. It was industrially synthesized by traditional process which generates more waste and used hazardous organic solvents. Hence, it is need to develop environmental benign catalytic synthesis of ibuprofen. We synthesized pearl necklace shaped gold nanostructured material with diameter about 4 nm. Gold nanoparticles (AuNPs) were prepared and tested for the activity in the catalytic reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) showed excellent catalytic performance. Further, using AuNPs we catalytically synthesized 1-(4-isobutylphenyl)ethanol which is important drug intermediate for the widely used Ibuprofen. The rate constants was determined at room temperature 0.167 ± 0.003 per minute. The recyclability study of AuNPs in the reduction of 1-(4-isobutylphenyl)ethanone (IBPEON) to 1-(4-isobutylphenyl)ethanol (IBPE) in six consecutive reaction cycles found to be (92%), (89%), (86%), (85%), (81%), (77%), respectively. We emphasized, the reported synthesis was smoothly performed in the mild reaction conditions under environmentally benign alternative.
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