Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Glycerol mediated safer synthetic route for pyrazolines bearing quinolino and benzene sulfonamido pharmacophores
Author(s): Glycerol mediated safer synthetic route for pyrazolines bearing quinolino and benzene sulfonamido pharmacophoresOrganic transformations need organic solvents. Most of the organic solvents which are in use while performing the transformations for obtaining products of societal use are volatile organics responsible for environmental pollution. These solvents are from exhaustible petrochemical source. Herein pyrazolines, 3-(4'-tosylaminophenyl)-5-(2'- chloro-substituted quinolin-3-yl)-4,5-dihydropyrazolines (2a-f) were synthesized from cyclocondensation of chalcones, 3-(2-Chloro-substitutedquinolin-3-yl)-1-(4-(tosylamino)phenyl)prop-2-en-1-ones(1) with hydrazine using greener medium, glycerol at 90 oC.
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