This study was designed to investigate the pharmacotoxicity of methanolic extracts of Punica granatum cortex and Zingiber officinales rhizome at different doses 800,400 and 200mg/kg to rats via oral route, The methanolic extract of Punica granatum cortex (400 mg/kg+ PHA) in days 45 showed significant increase in IL-2 and IL-6 level. While the methanolic extract of Zingiber officinales rhizome (400 mg/kg+ PHA) in days 45, showed significant increase in IL-10 level.
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