Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Fused pyrimidines: The heterocycle of diverse biological and pharmacological significance
Author(s): Vachala S. Dinakaran, Bhargavi Bomma and Keloth K. SrinivasanFusion of pyrimidine moiety with different heterocycle scaffolds gives rise to a new class of hybrid heterocycles possessing improved activity. Heterocycles containing sulphur and nitrogen atoms in the core structure, shows number of pharmacologically and biologically active compounds. So, various fused pyrimidines like purines, pteridines, quinazolines, pyridopyrimidines, triazolopyrimidines, pyrazolopyrimidines, pyrimidoazepines, furopyrimidines and pyrrolopyrimidines were studied in the past decade and were found to possess remarkable pharmacological properties. The present review provides a broad view of the biological and medicinal properties expressed by compounds having fused Pyrimidine nucleus.
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Citations : 15261
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