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Fused Pyrimidine Hybrids Facile Synthesis, Characterization and In vitro Antimicrobial Screenings | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Fused Pyrimidine Hybrids Facile Synthesis, Characterization and In vitro Antimicrobial Screenings

Author(s): Sumeet K Bhatia, Varsha Samdhian, Balbir Kaur

In the present study, we herein report the synthesis, characterization and in vitro antimicrobial investigations of 3-methyl-4-(substitutedphenyl)-1,7-diphenyl-1,4-dihydropyrazolo[3,4-d][1,3,4]-thiadiazolo[3,2-a]pyrimidine derivatives by following renowned Biginelli reaction using microwave irradiations. Agar Diffusion Method was employed to carry out anti-microbial activities. The synthesized fused systems were found to be entirely anti-bacterial in nature and compounds 4a, 4g possessing nitro and chloro substituent respectively, at ortho position on the aromatic ring at C-4, behaved as the most promising antibacterial moieties. None of the compounds showed antifungal activity.


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