Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Formulation and Characterization of Minoxidil Oral Thin Film
Author(s): Souli Dutta, Jayanta Chattopadhyay, Biswanath Ghosh, Diptendu Goswami and Suchandra Goswami*Objective: The primary aim of the current investigation was to formulate and assess immediate-release oral thin films of minoxidil, with the goal of increasing the bioavailability of the medication and accelerating its onset of action, thereby enhancing patient adherence.
Methods: Using a film-forming polymer such as hydroxypropyl methylcellulose, the solvent evaporation method was used to create instantrelease oral thin films of minoxidil.
Results: A number of physicochemical characteristics, such as drug content, in vitro drug release, folding endurance, tensile strength, thickness and weight change, were assessed for the films. Since the formed films F1-F9 were immediately wetted by the dissolving medium, no variations in the in vitro dissolution of the drug were observed. For the F8 formulations, the drug release was almost 94%.
Conclusion: The current formulation uses mouth-dissolved films that have a quick start of action to deliver medication properly and have good therapeutic efficacy when taken orally.
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