Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Formation and interpretation of new spiro thiadiazines
Author(s): Vijay V. Dabholkar, Prem Naik, Abhishek Karekar and Navnath ShindeEquimolar mixture of substituted triazole (1) and substituted aromatic aldehyde were refluxed in presence of alcoholic KOH to yield 4- substituted-banzylidene-amino-5-substituted-4H-1,2,4-triazole-3-thiol (2), which cyclized to form 2H,3H,4H,2-Carbethoxy, 3-substituted, Phenyl,5-substituted-[1,2,4]-triazole [3,4-b] [1,3,4] thiadiazine (3) using ethyl chloro acetate and K2CO3. Compound (3) was undergoes bromination in the presence of iodine which is act as catalyst to form Bromo compound (4). Compound (4) was further converted into Imino spiro Thiadiazines (6), Hydrazino spiro Thiadiazines (8) and spiro Triazolo-thiadiazines (9) by reacting with Thiosemicarbazones (5), Thiocarbohydrazones (7) and Triazoles (1) respectively. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR and mass spectroscopic analysis.
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