Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Fibroblast growth factor (FGF) identification of a fertilized chicken egg whites and their effects on stem cells regeneration in the pancreas of hyperglycemia mice
Author(s): Dharma S, Irene Puspa Dewi, Marlina and Dillasamola D.This research aims to identify Fibroblast Growth Factor (FGF) in fertilized chicken egg whites and to see the effects of the FGF on the regeneration of stem cells in the pancreas of hyperglycemiamice. FGF identification in fertilized chicken egg whites utilizes Enzyme-Linked Immunosorbent Assay (ELISA)method. The examination of FGF effectson the regeneration of stem cells in the pancreas ofhyperglycemia miceis carried out in vivo by giving out the prepared eggwhites containing FGF indosage of 4 mg/20 g for 28 days. Then the writer observed the pancreatic histopathology using Hematoxylin-Eosin (HE) reagents and ImmunoHistoChemistry (IHC) reagents. FGF identification yielded by ELISA was positive with levels of 219 ng/L. Histopathological observations showed that the induction of FGF derived from fertilized chicken egg whites repaired cell morphologyof pancreatic endocrine and increased insulin secretion in pancreatic β cells. FGF derived from fertilized chicken egg whites helps the regeneration of stem cells in the pancreas of mice hyperglycemia.
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Citations : 15261
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