Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Facile synthesis of thiazolidinones bearing thiophene nucleus as antimicrobial agents
Author(s): Raghav Mishra, Isha Tomar, Sachin Singhal, K. K. JhaA series of thiophene derivatives was synthesized with an objective to develop novel and potent antimicrobial agents of synthetic origin. The required starting material ethyl-2-amino-4,5,6,7- tetrahydro-1-benzothiophene-3-carboxylate(1) was synthesized via a multicomponent condensation between sulphur, cyclohexanone and ethylcyanoacetate adopting Gewald Reaction. The Compound 1 was reacted with various substituted aldehydes to synthesize Schiff bases which on cyclization with thioglycollic acid in catalytic amount of ZnCl2 yielded the final products (R1-R9). Synthesized compounds were purified, characterized and evaluated for their antimicrobial activity. Most of the compounds exhibited moderate to significant activities.
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Citations : 15261
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