Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Evaluation of stability constants of 1-(3-bromo-4-hydroxy-5-methoxy benzylidene) thiosemicarbazide(TRM-1) with copper (II), cobalt (II) and nickel (II) complexes by pH metric method
Author(s): Rakesh M. Tada, Pankaj B. Nariya, Naimish K. Chavda and Manish K. ShahThis study was taken out for determine the stability constants of the complexes of 1-(3-bromo-4-hydroxy-5- methoxybenzylidene) thiosemicarbazide (TRM-1) in Dioxane: Water ratio 60: 40 (V/V) mixture by pH-Meter. The proton-ligand and metal-ligand stability constants of Cu(II), Ni(II) and Co(II) metal ions with TRM-1 have been performed pH metric method at 0.1 M ionic strength at 30°C ± 0.2°C temperature. The Proton-ligand stability constants H pKlog 1 , log pK2H and logb H is 10.66, 3.11 and 13.77 respectively and the Metal ligand stability constants is determine different Computational Methods.
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