Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Evaluation of oxidative stress induced by nanoparti cles (ZnO) on a unicellular biological model ( Saccharomyces cerevisiae )
Author(s): Mohamed Nabil Khebbeb*, Mohamed Reda Djebar, Amina Saib and Houria BerrebahThe aim of this study was to evaluate the ZnO nanop articles toxic effect on yeast Saccharomyces cerevi siae. Oxygen consumption, reduced glutathione content and enzyme activities (glutathione S-Transferase, Guaïacol an d Ascorbate Peroxidases) of Saccharomyces cerevisiae were evaluated after ZnO nanoparticles treatment at different concentrations. Obtained results showed that ZnO ca used an inhibition of growth kinetic and oxygen con sumption. Evaluation of oxidative stress biomarkers revealed that ZnO treatment resulted in a decrease of reduce d glutathione concentration and an increase of all enzyme activit ies. These results suggested that ZnO nanoparticles caused an oxidative stress to yeast S. cerevisiae. Consequently, yeast could be a suitable model for assessment nanoparti cles toxicity.
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