GET THE APP

Electrochemical sensor for the detection of mefenamic acid in pharmaceutical sample and human urine at glassy carbon electrode | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Electrochemical sensor for the detection of mefenamic acid in pharmaceutical sample and human urine at glassy carbon electrode

Author(s): Shikandar D Bukkitgara, Nagaraj P Shettia*, Deepti S Nayaka, Gangadhar B Bagehalli and Sharanappa T Nandibewoor

The electrochemical oxidation of mefenamic acid has been investigated by cyclic, linear sweep and differential pulse voltammetry in phosphate buffer of different pH range 3-11, at glassy carbon electrode. Cyclic voltammetric studies were performed in a wide range of sweep rates and various concentration of mefenamic acid. The effect of surfactant was studied. The anodic peak was characterized and the process was adsorption controlled. The linear relationship between peak current and the mefenamic acid concentration were studied using differential pulse voltammetric technique, for the quantitative determination of mefenamic acid. The linear response was obtained in the range of 8 x 10-5 to 2 x 10-3 M with detection limit of MFA 1.49 x 10-7 with good selectivity and sensitivity. Furthermore, the proposed method was applied to in-vitro determination of mefenamic acid in pharmaceutical sample, spiked human urine by adopting the differential pulse voltammetric technique.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry