Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Effects of Binder on the Physico-chemical Properties and the Quality of Paracetamol Tablets
Author(s): Sunethra K. Gunatilake, Sethsiri S. Samaratunga and Folahan A. AdekolaA laboratory study was done to evaluate the effects of binder on the physico-chemical properties and the quality of paracetamol tablets prepared by the wet granulation method using three different binders, namely, polyvinyl pyrrolidone (PVP), starch paste and gelatine solution. Tablets were evaluated for uniformity of weight and drug content, hardness & tensile strength, friability, disintegration time and dissolution rate. Results indicated that tablet weights measured for formulation 1, 2 & 3 were well within the ranges, (253.5 ± 12.7), (230.2 ± 17.3) and (238.1 ± 17.9) according to BP standard, respectively. Hardness, tensile strength, and disintegration time evidenced that the gelatine solution appeared to be the best for paracetamol tablet than PVP and starch paste. Friability and dissolution rates were not in agreement with other parameters. It was found that the strength of inter- and intragranular forces plays key role in maintaining quality of tables. All parameters are dependent on the type, quality, concentration and degree of spreading of a binder
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