Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Effect of Soy (Glycine max) Against Alcohol-Induced Biochemical Alteration in Liver of Male Albino Rat
Author(s): Ikenna K Uchendu, Chidozie E Agu, Oliver C Orji, Eluke B Chekwube, Ikechukwu J Chukwu, Nnedu E Bitrus, Tochi F Nwosu, Oluwanifemi P AparaAlcoholic liver damage has become common among the populace. The economic situation and poverty level have made alcohol consumption high among the population; as people tend to resort to high alcohol consumption to give them succor. Soybean is known for its pharmacologic and nutritional properties. The aims of this study were to analyze the phytochemicals present in soybean and investigate the effect of soybean against alcohol-induced liver disease. In this study, twenty-four (24) male albino Wister rats weighing (200-220 gm) were divided into four (4) groups: group 1 served as normal control and received only distilled water, group 2 as positive control and was given ethanol plus vitamin C (200 mg/kg, oral),group 3, the test group was given ethanol plus soymilk (2000 mg/kg, oral), and group 4, the negative control was given ethanol alone (2000 mg/kg, oral) for twenty one (21) days. Albumin, total bilirubin, conjugated bilirubin, aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) levels were evaluated using Rx Monza analyzer and standard laboratory kits from Randox laboratories, UK. The results showed a significant decrease in levels of serum bilirubin, and a significant decrease (P<0.05) in levels of serum enzyme markers of liver damage from 101.00 Ã?â??Ã?± 2.08, 100.00 Ã?â??Ã?± 1.16, 576.00 Ã?â??Ã?± 36.10 to 73.70 Ã?â??Ã?± 6.98, 77.33 Ã?â??Ã?± 1.76, 400.00 Ã?â??Ã?± 20.80 for AST, ALT, and ALP respectively (P<0.05), when compared with the ethanol-only group (negative control group). Therefore, the results suggest that soymilk has the ability to significantly reduce/lower the effects of alcoholic damage to the liver.
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