Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Eco-friendly Synthesis of α -Aminonitriles Catalysed by Epzg
Author(s): Rahul Patil*, Ankush Mali, Shivaji Burungale, Uday Lad, Sanjay Jadhav and Uttam MoreA simple, proficient and ecofriendly procedure has been developed for the three component coupling of aromatic aldehyde, substituted amines and trimethylsilyl cyanide produce α-amino nitriles. The α-amino nitriles are synthesized in high yields (90-91%) in a few minutes (18-45 min) under solvent-free conditions using EPZG catalyst at room temperature.
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