Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Does Lycopene Tomato Paste Consumption Effectively Decrease Clastogenicity in Streptozotocin-Induced Diabetic Rats?
Author(s): Aly Ezz El-Arab, Shenouda M Girgis, Walaa S Amin, Shafika A ZakiThe present study was designed to determine the possible therapeutic effects of oral tomato paste lycopene supplementation on clastogenicity induced by hyperglycemia in diabetic rats. Diabetes was induced by streptozotocin (STZ) injection. Twenty eight male Wistar rats were divided into 4 groups (7 rats per group) as follow: 1-The first group served as control. 2-The second was a diabetic (STZ induced) group, 3-The third was a diabetic+lycopene treated group and 4-The fourth was a lycopene treated group. The treatment period was 2 months and the animals were subjected to micronucleus assay. The results of the present study revealed that a significant increase in micronucleus frequency in the diabetic group (STZ-induced) compared to control. However, supplementation with lycopene in STZ-induced diabetic group decreased significantly the incidence of MN frequency and restores the MN range to the normal control. In conclusion, oral tomato paste lycopene supplementation effectively decreases clastogenicity in Streptozotocin-induced diabetic rats through its antioxidant activity.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
