Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
DNA damage responses to oxidative stress in tilapia (Oreochromis mossambicus) exposed to polluted water
Author(s): Bamini B, *Ganesan S. and Kavitha PThe aim of the present investigation was to assess the biological damage and oxidative stress caused by exposure of the test organism (Oreochromis mossambicus) to various mutagenic agents present in the polluted waters of the Chrompet Lake, located in Chennai, Tamil Nadu, India. This urban lake receives domestic, industrial waste discharge and storm water runoff. The evaluation of the quality of the water of Chrompet Lake is important and necessary, since it is utilized for domestic and recreational purpose. In addition, the aim was to collect data with respect to the validation of the comet assay as a biomarker in fish and on the utilization of O. mossambicus as a bioindicator of genotoxicity in environmental impact assessment of continental waters. For this purpose, we performed a single cell gel electrophoresis (the Comet assay), testing DNA migration in an electrophoretic field using erythrocytes of O. mossambicus, both from the Chrompet Lake and the fish reared in the laboratory condition as negative control. The results of the experimental fish revealed a significantly greater number of comets and suggested a genotoxicity of the aquatic environment at Chrompet Lake. The comet assay in O. mossambicus provides an adequate sensitivity to be utilized as a tool in the monitoring of water pollution and environmental risk assessment.
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