Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Development of Visible Spectrophotometric Methods for the Determination of Ranolazine in Bulk and Pharmaceutical Dosage Form
Author(s): Magesh AR*, Kavitha D and Dhanaraju MDTwo precise, accurate and simple visible spectrophotometric methods were developed for the determination of Ranolazine in bulk drug and in pharmaceutical dosage form. The proposed methods were based on determination of ranolazine after its reaction with 3-Methyl-2-benzothiazolinone hydrazine hydrochloride and potassium dichromate and measuring the chromogen at the λmax at 661 and 432, respectively. Beer’s law obeyed in the concentration range of 50-150 μg/ml for Method A and 25-125 μg/ml for Method B. The accuracy of the methods was calculated by performing recovery studies. The methods were found to be simple, economical, accurate and reproducible and can be used for routine analysis of Ranolazine in bulk drug and in pharmaceutical formulations.
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Citations : 15261
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