Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Development of UV spectroscopic method for the estimation of s(-) Amlodipine and Hydrochlorothiazide in dosage forms by simultaneous equation method
Author(s): J. Bagyalakshmi*, Sincy Mary Philip and T. K. RaviS(-) amlodipine is a potent calcium channel blocker used for the treatment of hypertension, congestive heart failure and angina pectoris. S(-) amlodipine avoids the adverse effect of amlodipine in racemic mixtures. Hydrochlorothiazide is a first line diuretic drug of the thiazide class used for the treatment of hypertension, congestive heart failure and symptomatic edema. Literature review indicated that, various methods have been reported for the analysis of S(-) amlodipine and hydrochlorothiazide in formulation by RP-HPLC, HPTLC. But no analytical methods were reported for the estimation of these drugs using UV spectroscopic by simultaneous equation method.
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Citations : 15261
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