Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Development of RP-HPLC method for estimation of Olmesartan Medoxomil in tablet dosage forms
Author(s): Chaitanya prasad MK, Vidyasagar G, Sambasiva Rao KRS and Ramanjeneyulu SReversed phase high performance liquid chromatographic method was developed and validated for the estimation of Olmesartan medoxomil in bulk and formulation. Selected mobile phase was a combination of phosphate buffer with pH adjusted at 2.8 and acetonitrile (35:65% v/v) and wavelength selected was 250 nm. Retention time of Olmesartan medoxomil was 2.591 min. Linearity of the method was found to be 50-150 μg/ml, with the regression coefficient of 0.9993. Quantification was done by calculating area of the peak and the detection limit and quantitation limit ware 0.02μg/mL and 0.09μg/mL, respectively. There was no significant difference in the intraday and inter day analysis of Olmesartan medoxomil determined for three different concentrations using this method. Present method can be applied for the determination of Olmesartan medoxomil in quality control of formulation without interference of the excipients.
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