Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Development and Validation of Visible Spectrophotometric methods for the Estimation of Mesalamine in Pharmaceutical Dosage Forms
Author(s): Venugopal Darak, Aravind Karadi, MD Arshad and SajjaAppalrajuThreesimple and sensitive spectrophotometric methods (A, B and C) have been developed forthe quantitative determination of Mesalamine in bulk drug and pharmaceutical preparations.Method A, B are based on the condensation of Mesalamine with p-dimethyl aminobenzaldehyde and pdimethyl amino cinnamaldehyde to form schiff’s bases, to yield a yellow, red colored chromogen and exhibits absorption maxima at 440, 523.5 nm. Method C isbased on the reaction of Mesalamine with Folin-Ciocalteu (phenol’s) reagent under alkaline conditions forming a blue colored chromogen and exhibits absorption maxima at 616 nm. Beer’s law was obeyed inthe concentration range of 50-250, 20-100 and 10-50μg/ml for method A,B and C respectively. Thesemethods were extended to pharmaceutical formulations and there was no interference from any common excepients. The results of analysis have been validated statistically and by recoverymethods.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
