Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Development and validation of an UV derivative spectrophotometric determination of Losartan Potassium in Tablet
Author(s): Amna B. W. E. Mohammed and Elsadig H. RudwanA simple, sensitive and accurate, low cost and requires relatively inexpensive instrument, then it is good alternative to existing method for determination losartan potassium in tablet . Pharmacopeias have not yet provided an official method for its quantification. Losartan potassium, the method employed is a first derivative spectroscopy a signal at 234 nm of the first derivative spectrum was found adequate for quantification. The linearity between signal 1D234 and concentration of Losartan potassium in the range of 4.00-14μg/ml in aqueous solutions presents a square correlation coefficient (r2) of 0.9996, .the recovery studies confirm accuracy of proposed method and low values of standard deviationconfirm precision of the method, the method is validated as per ICH guideline
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Citations : 15261
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