Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Determination of optimal conditions for the dosage of selenium in whole human blood by differential pulse cathodic stripping voltammetry
Author(s): Tarik. ATTAR, Yahia. HAREK, Nouria. Denouni-Medjati, Lahcen. LARABIThe objective is the determination of the conditions operating optimal to determine the concentration of the selenium dissolved in the human blood. An electroanalytical method has been developed for the determination of selenium in whole blood by differential pulse cathodic stripping voltammetry (DPASV) on a hanging mercury drop electrode (HMDE). The best conditions were found to be electrolyte support 200 μg mL-1 of copper in HCl 0.3M, the accumulation potential is -325 mV and the accumulation time is 300 s. The optimum value of stirring rate was determined to be 400 rpm. Calibration curve is linear in the range 9.75 10-3 to 3.25 μg L-1 with a detection limit of 29 μg L-1. The correlation coefficient and relative standard deviation were 0.9999 and 1.62%. The developed method was validated by the analysis of reference materials certified by total blood.
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Citations : 15261
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