Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Design, synthesis, characterization and bioassay of novel amide derivatives of 2-(benzo[d]thiazol-2-yl)phenol
Author(s): Sreedhar B., Veera Reddy T., Naga Raju C., Padmavathi V. and Vidya Sagar Reddy G.A series of new carboxamide derivatives of 3-(2-(benzo[d]thiazol-2-yl)phenoxy)propanoic acid (2) were synthesized by the reaction of 3-(2-(benzo[d]thiazol-2-yl)phenoxy)propanoyl chloride (3) with various bio-potent amines by using 1-methylimidazole as an acid scavenger via Schotten-Baumann reaction. The newly synthesized compounds were characterized by IR, NMR and mass spectral analysis. The title compounds were evaluated for their efficacy as antibacterial and antifungal agents in vitro. Compounds 4e-h showed high inhibitory activity against both bacteria and fungi.
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