Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Design, synthesis and spectral characterisation of novel acyclic ligand and their transition metal complexes as selective DNA binding agents
Author(s): C. Joel, S. Theodore David, R. Biju Bennie, S. Daniel Abraham, S. Iyyam PillaiNovel Co(II), Ni(II), Cu(II) and Zn(II) complexes have been designed and synthesized using the Schiff base ligand derived from 9,10-phenanthrenequinone and benzylamine. The ligand and its complexes have been characterized by analytical and spectral techniques. The higher conductance values in DMSO indicate that the complexes are 2:1 electrolytes. On the basis of electronic spectral investigations square planar geometry was assigned to Co(II), Ni((II) and Cu(II) complexes. The interaction of the complexes with CT-DNA has been explored by absorption, emission, circular dichoric and viscosity measurements. The complexes exhibited hypochromicity in absorption, which revealed that the complex bound to CT-DNA through an intercalation mode.
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Citations : 15261
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