Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Design, Synthesis and Bioevaluation of New Urea/Thiourea Derivatives of 3,5-dichloro-4-hydroxy-aniline
Author(s): Chamarthi Naga Raju, Kollu Umapriya, Pandreti Vedavathi, Kuruva ChandrasekharSynthesis of a series of new urea and thiourea derivatives of 3,5-dichloro-4-hydroxyaniline was accomplished by reacting various isocyanates and isothiocyanates in the presence of triethylamine at 60°C. All the title compounds obtained in high yields and they were characterized by IR, 1H, 13C-NMR, mass spectral and elemental analysis. All the title compounds exhibited potent antioxidant and antimicrobial activities.
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