Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Design and synthesis of substituted clubbed triazolyl thiazole as XDR & MDR antituberculosis agents Part-II
Author(s): Dinkar Mundhe, A. V. Chandewar, M. R. ShiradkarMedicinal chemist are striving to arrive at a promising anti-tubercular agents which can be effective against XDR & MDR tuberculosis. This has made them to work non-conventionally to arrive at promising “Hit”. This article describes synthesis and antimycobacterial activity of clubbed thiazolyl-triazole molecule which are synthesised overriding the Lipinski rule of five. The compounds have shown potency comparable with isoniazid even with 25 XDR & MDR clinical isolates. The candidate is under further development status and is showing promising activity with minimal toxicity.
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Citations : 15261
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