Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Design and synthesis of some new imidazole and 1,2,4-triazole substituted fluorobenzimidazoles for antitubercular and antifungal activity
Author(s): B. Nandha*, L. V. G. Nargund and S. L. NargundA series of thirteen imidazole and 1,2,4-triazole substituted fluoro benzimidazoles (8a-i), (9a-b) and (11a-b) with phenyl and benzyl group at 2nd position were synthesized and screened for antitubercular activity against H37RV strain and antifungal activity against Candida species. Both imidazole and 1,2,4-triazole substituted fluoro benzimidazoles with 2-benzyl and 4-N(CH3)2 substituted 2-phenyl/2-phenyl-1-benzyl counterpart were found to be the most active of all the compounds. To examine the influence of azole moiety on the activity chlorine substituted fluoro benzimidazole (5) was synthesized. The newly synthesized compounds were characterized by I.R, 1H-NMR, 13C-NMR, Mass and elemental analysis. In vitro antitubercular and antifungal activity data revealed that the benzimidazole scaffold with imidazole or triazole moiety were important for antitubercular and antifungal activity.
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Citations : 15261
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