Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Design and Synthesis of Flavonoid Derivatives as Anti-inflammatory Drug
Author(s): Seema P Rathod* and Awinash S ChavanA series of 2-(3’-aminesubstituted)-7-hydroxyl-4H-1-benzopyran-4-one amine derivatives has been synthesized on the basis of molecular docking results. The novel derivatives prepared by condensation of 2,4-Dihydroxyacetophenonee (1.40 ml) and 3-chlorobenzaldehyde (0.01 mole) through Claisen-Schmidt condensation reaction. Novel flavone derivatives were access for anti-inflammatory activity by using carrageenan induced rat paw edema method. Among the synthesized compounds (t, v, w, k) shows good anti-inflammatory activity comparable to reference drug (Celecoxib).
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