Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Design and Release of Carbamazipine Extented Release Matrix Tablets
Author(s): Dhruv KumarEpilepsy is a chronic condition of the central nervous system, number of situation consuming in public unusually working brain cell, advent of motor, sensory autonomic and psychic index. Carbamazepine reduces discomfort related thru trigeminal neuralgia after 24-48hrs.The immediate discharge tablet of CBZ essential to be managed 3-4 times a day. Prolonged discharge matrix preparation of CBZ (200mg) has great effect to manage it.
Methodology: Crystalline properties of CBZ in continue discharge hydrophilic matrix tablet founded on hydroxyl propyl methyl cellulose (HPMC).
Hydrophilic matrix system reduces the frequency of drug dosing.
Hydrophilic matrix tablet of CBZ utilse hydroxyl propyl methyl cellulose of low viscosity grade in the concentration of 27.85% was developed.
Result: Presence of sodium lauryl sulphate (SLS) in the preparation improves the solubility of the CBZ permitted extra than 98.1% of CBZ to discharge of the finish of 24hrs.
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Citations : 15261
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