Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Derivative spectrophotometric method for simultaneous determination of cilnidipine and olmesartan medoximil in tablet dosage form
Author(s): Mital Sidhdhapara, Biraju Patel, Ashok Parmar, Hitesh Vekariya and Piyush PatelThis study describes the development and validation for the simultaneously estimation of cilnidipine and olmesartan medoximil in combined tablet dosage form by first order derivative UV spectroscopic method. The quantification was achieved the first order derivative method at 256 nm and 220 nm over the concentration range of 2-10 μg/ml for cilnidipine and 4-20 μg/ml for olmesartan medoximil in a combined tablet formulation. Procedure does not require prior separation of components from the sample. LOD values for CIL and OLM are found to be 0.67 μg/ml and 1.90 μg/ml respectively. LOQ values for CIL and OLM are found to be 2.04 μg/ml and 5.77 μg/ml respectively. The result of analysis has been validated statistically and recovery studies carried out in the range of 80-120 % to confirm the accuracy of the proposed method. The relative standard deviation was found to be < 2.0%. The present result shows that the proposed method can be successfully used for simultaneous determination of the drug content in marketed formulation.
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