Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Cyanoacetic acid promoted an eco-expedient synthesis of bis(indolyl)methanes at ambient temperature condition
Author(s): Dadasaheb K. Salunkhe and Madhukar B. DeshmukhWater mediated green reaction of indole with substituted aryl aldehydes in order to generate bis(indolyl)methanes using cyanoacetic acid as a catalyst has been established. High yields and a simple workup enable the convenient generation of the target compound at room temperature. Herein we have reported an efficiently inexpensive synthetic protocol to obtain these fascinating molecules which undoubtedly constitute a vital structural motif.
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Citations : 15261
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