Polyphenols are beneficial phyto-compounds with antioxidant properties that protect from various diseases such as cardiovascular, cancer and diabetes mellitus. Among various diseases, we hereby focus on the applications of polyphenols primarily for diabetes mellitus, which is related to a dysfunction in the β-cells of the pancreas that outcome defective production and release of insulin. Here, we primarily discuss the role of curcumin and quercetin in the therapeutics of diabetes, as both polyphenols are highly potent antioxidants and their combination in a novel delivery system that would show positive effects in the management of diabetes and its complications.
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