Abstract

Curcumin and Ascorbic Acid Therapeutic Benefits in a Female Wistar Rat with Renal Tissue UVB-Induced Hyperthyroidism: A Histological and Biochemical Study

Author(s): Gayatri Rai, Shashank Shakyawal, Narendra Namdev and Payal Mahobiya*

Renal issues are a major problem for humanity. The renal system may sustain damage from the potentially dangerous radiation. Therefore, the purpose of this study is to evaluate how well curcumin and ascorbic acid protect kidney tissue from being altered by UVB-induced hyperthyroidism in female Wistar rats. Twenty-four female’s sexually older Wistar rats weighing 130 g-150 g and aged 12-16 weeks were arbitrarily divided into four groups. The control group received normal food and water ad libitum. The UVB group was exposed to a dose of 280 nm of UVB radiation for 2 h daily. The UVB⁺ curcumin group received a dose of 280 nm of UVB radiation for 2 h daily and also an oral dose of curcumin (25 mg/kg body weight) daily. The UVB⁺ ascorbic acid group received a dose of 280 nm of UVB radiation for 2 h daily and also an oral dose of ascorbic acid (250 mg/kg body weight) daily. All the treatments last for 15 consecutive days. Body and kidney weight were measured. The histology of kidney tissue was done by H and E, PAS, MBB and Sudan black B staining and observed. The biochemical changes were measured by particular methods. UVB radiation caused histological and biochemical changes in Wistar rats, while curcumin and ascorbic acid protected these changes, with ascorbic acid showing greater protection. Curcumin and ascorbic acid at low doses can alleviate changes made in histology and biochemical reactions in cells induced by UVB radiations in female Wistar rats.

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