Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Condensation-cyclodehydration of 2,4-dioxobutanoates: Synthesis of new esters of pyrazoles and isoxazoles and their antimicrobial screening
Author(s): Naqui Jahan Siddiqui and Mohammad IdreesA series of new substituted/unsubstituted pyrazole-3-carboxylates (2-3a-d) and isoxazole-3-carboxylates (4a-d) were synthesised by the reaction of methyl 4-(substituted/unsubstituted benzofuran-2-yl)-2,4-dioxobutanoates (1a-d) with active nitrogen-centered nucleophiles (hydrazine hydrate, hydroxylamine hydrochloride and semicarbazide hydrochloride) involving condensation-cyclodehydration of 2,4-dioxobutanoates. Constitutions of the synthesised compounds have been delineated on the basis of chemical transformations, elemental analysis, IR, 1H NMR, 13C NMR and Mass spectral studies. The title compounds were evaluated for their antimicrobial activity against gram positive and gram negative bacteria as well as a fungus.
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