Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Comparision of Anti-diabetic Activity of Plant Based and Synthetic Aryltetalin Derivatives
Author(s): Chaitramallu M*, Parvathi G R, Sindhu GM and Ranjini PThe aryltetralin compound podophyllotoxin was extracted from the roots of plant P. peltatum and analogues of aryltetralin were synthesized using tetralone as a starting material. They were synthesized by replacing 1, 3‐methylene dioxy ring with dimethoxy, hydroxy, methyl, chlorine and hydrogen and methoxy group. The structure of the final compounds was confirmed by 1H NMR, 13C NMR, mass spectra and elemental analysis data and the analogues were screened for anti-diabetic activity. It is noteworthy that, all the synthesized derivatives exhibits good anti-diabetic activity with respect to standard reference.
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