Substituted Carboxylic acid condensed with Thiosemicarbazide to form 2-amino-5-substituted 1,3,4-Thiodiazole in various reaction conditions. Present work is comparative study of synthesis of 2-amino- 1, 3, 4-Thiodiazole with respect to yield, reaction time and reaction conditions. All products are characterized by spectral data and elemental analysis.
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