Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Comparative studies of novel triazole derivative having chiral center and their antimicrobial activities
Author(s): Bhavnaben D. Mistry*, Kishor R. Desai and Sanket M. Intwala(-)5-[(1S)amino (2-chlorophenyl )methyl]-4-substituted phenyl-1,2,4-triazole-3-thiol (11a-j) & (+)5- [(1S)amino (2-chlorophenyl) methyl]-4-substituted phenyl-1,2,4-triazole-3-thiol (12a-j) have been synthesized by the reaction of (-)5-[(1S)amino(2-chlorophenyl)methyl]-1,3,4-oxadiazole-2-thiol (9) & (+)5-[(1S)amino(2-chlorophenyl)methyl]- 1,3,4-oxadiazole-2-thiol (10) with con. H2SO4, L(+) Tartaric acid, L(-) Tartaric acid, Hydrazine Hydrate, carbon disulfide and Various aromatic amine respectively. These compounds have been screened for their antibacterial and antifungal activities against different microorganisms. The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR,13C NMR and mass spectral data.
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