Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Comparative preliminary phytochemical and biological investigations on Andrographis paniculata (Nees) and Aristolochia indica (Linn)
Author(s): S. M. Moazzem Hossen, Md. Shakhawat Hossain, Jahidul Islam, M. Nurunnobi Pinto, Nur-E-Jannat, Firoj AhmedForemost objective of the present research was Phytochemical and biological activity investigations of methanolic extract of Aristolochia indica (Linn.) (Aerial part) and leaves of Andrographis paniculata (Nees). The identifications of phytochemical carried out by following standard chemical procedure. Anti-oxidant activity screening was performed by free radical scavenging method, anti-bacterial activity by disc diffusion method and cytotoxic activity by brine shrimp lethal bioassay. The results showed the plant extract contains many phytochemical compounds. Methanolic extract of Andrographis paniculata (Nees) showed strong antioxidant and cytotoxic activity. On the other hand, Aristolochia indica Linn showed moderate cytotoxic activity and mild antioxidant. The present study Andrographis paniculata (Nees) showed strong anti oxidant and cytotoxic activity suggests future higher research study. The plant available in Bangladesh and could be prominent source of medically important natural compound.
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