Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Cobalt (Ii), Nickel (Ii), Copper (Ii) and Zinc (Ii) Complexes of New N, N-Bis (Thiophen-2-Ylmethylene) Benzene-1, 2-Diamine: Synthesis, Spectroscopic and Antibacterial Studies
Author(s): Sanjeev A, Bhaskar S, Nasreen SK, Naresh Reddy N, Karunakar D, Ramesh P, Muralidhar Reddy PCobalt(II), Nickel(II), Copper(II) and Zinc(II) complexes with N,N-bis(thiophen-2-ylmethylene)benzene-1,2-diamine ligand have been synthesized and characterized by UV-Visible, Infrared, mass, electronic and Proton Nuclear Magnetic Resonance (1H-NMR) spectral data. Spectral data suggest that Co(II), Cu(II) and Ni(II) complexes with octahedral geometry and the Zn(II) complex with a tetrahedral structure. The antibacterial activity of all the ligands and complexes against gram-positive bacteria (Bacillus subtilis)/gram–negative bacteria (Escherichia Coli A+ and E. Coli strain Top-10) was compared with the activity of existing commercial antibacterial compound like ampicillin. All metal complexes found to be more active than respective ligand.
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