Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Chemistry of novel piprazine-thiazole derivatives- their synthesis and microbial evaluation
Author(s): Vijay V. Dabholkar, Navnath Shinde and Sunil Rajaram PatilCompound 1 was converted into its Acid derivative using aq sodium hydroxide solution (2), which on further treatment with thionyl chloride to yield the respective acid chloride (3) which was further treated with the ammonium isothiocynate & aromatic amine to give the respective phenyl thioureas derivative (4) ,which further react with 2-bromo-acetophenone to give Thiazolo (5) derivatives. The structures of the synthesized compounds were confirmed by Physico-chemical test and spectral techniques. Representative samples were screened for their antimicrobial activity against gram positive and gram negative bacteria.
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