Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Boric acid promoted an efficient and practical synthesis of fused pyrimidines in aqueous media
Author(s): H. M. Meshram, A. Sanjeeva Kumar, G. Santosh Kumar, A. Swetha, B Chennakesava Reddy, P. RameshA very efficient, convenient, mild and practical method is described for the synthesis of fused pyrimidines by three component reaction of β-keto ester, aldehyde and heterocyclic amine in the presence of boric acid in water. The reaction proceeds at rt and yields are high. The method is also amenable for the synthesis of new thiazodihydropyrimidine compounds.
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