Halogenosubstituted vanillins were prepared by halogenations. Halogenosubstituted vanillins on Knoevenagel condensation with malonic acid to form halogenosubstituted cinnamic acids by using conventional method as well as microwave irradiation technique. All halogenosubstituted cinnamic acids were screened for antibacterial activity. All newly synthesized halogenosubstituted cinnamic acids showed antibacterial activity to a remarkable extent.
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