Abstract

Assessment of Antidiabetic Activity by Using Silvernanoparticles of Arctium minus Leaves in Wistar Albino Rats

Author(s): Anusha Jasmin RJ*, Ramalingam Kothai and Balasubramanian Arul

Diabetes mellitus type 2 is one of the most frequent metabolic illnesses and it is characterized by an elevated blood sugar level owing to decreased insulin production or impaired insulin action or both. Diabetes Mellitus Type 1 is one of the rarest metabolic disorders. Metformin is most often used for the treatment of type 2 diabetes mellitus, but due to its slow mode of action and severe adverse effects, it exhibits a poor and delayed therapeutic response in patients. Now, researchers are working on creating nanomedicine to overcome these constraints. This study intends to explore the therapeutic potential of silver nanoparticles as an antidiabetic medication on streptozotocin-induced diabetic mice. The silver nanoparticles were prepared using the aqueous extract of Arctium minus and were characterized by UV, ATR-FTIR, TEM, EDAX and SEM analysis. Acute toxicity study was carried out in rats using OECD 423 and were found to be non-toxic. They were evaluated for them in-vivo antidiabetic activity using streptozotocin-induced diabetic rats. Arctium minus mediated silver nanoparticles possess strong antidiabetic potential and can further be explored as an effective and cheaper alternative option for treatment of Type 2 Diabetes Mellitus.

Full-Text PDF

30+ Million Readerbase

Google Scholar citation report

Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons