Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Anti-ulcer activity of methanolic extract of Hibiscus cannabinus (Leaves) in wistar strain rats
Author(s): Silambujanaki P, Chitra V, Hari DurgaPrasad K, Raju D, Sankari M, Soni DThe anti-ulcer activity of methanolic extract of leaves of Hibiscus cannabinus (Malvaceae) MEHC was investigated by Pylorus ligation and Indomethacin (8mg/kg;p.o) induced ulcer models in wistar rats. Ulcer index was used as the common parameter to determine the activity. MEHC at doses of 1.6 & 3.2g/kg p.o produced significant inhibition of the gastric lesions produced by Pylorus ligation & indomethacin. It also significantly (P<0.05) reduces gastric volume, free acidity and ulcer index as compared to control. The data obtained suggests that MEHC possess potent anti-ulcer activity ie.,antiulcerogenic and ulcer healing properties, which might be due to its antisecretory activity. The presence of flavanoids in the extract supports its activity. Hibiscus cannabinus (Malvaceae) commonly known as Mesta is cultivated all over India. In ayurvedic medicine, leaves are used in the treatment of dysentery and bilious, blood and throat disorders. The seed possess pain reducing effect when applied externally. It effectively delayed the onset of cataract formation.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
