Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Antioxidant properties and growth-inhibitory activity of coumarin Schiff bases against common foodborne fungi
Author(s): Maja Molnar, B. Ãâ¦Ã arkanj, M. ÃâÃÅaÃâÃÂiÃâÃâ¡, L. Gille and I. StrelecA series of coumarinylSchiff bases were examined for their antifungal, antioxidant (1,1-diphenyl-2-picryhydrazyl (DPPH) free radical and galvinoxyl radical scavenging activity) and metal chelating activity. Coumarin derivatives possessing dihydroxyphenyl moiety showed the best antioxidant activity in all antioxidant assays applied. High correlation between DPPH and galvinoxyl scavenging activity (r = 0.8238; p <0.05) was observed. Antifungal activity tests were performed against four common mycotoxin producing foodborne fungi, Aspergillusflavus, A. ochraceus, Fusariumgraminearum and F. verticillioides. Compounds bearing dihydroxyphenyl moiety were also proven to be an excellent antifungals.
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Citations : 15261
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